Comprehensive serological strategy for the diagnosis and monitoring of SARS-CoV-2. From infection to vaccine control

SARS-CoV-2 serology is useful to identify past COVID-19 cases, and it is not useful for acute infection. Levels of specific SARS-CoV-2 anti-N and especially anti-S are expected to be maintained for long periods. At this moment there is not a clear correlate of protection after COVID-19 or vaccination, therefore serological follow up is not indicated in most cases.